Proteina S100A10 coinvolta nella diffusione dei tumori
Scritto da Redazione di Gaianews.it il 31.10.2011
Gli scienziati della Dalhousie University di Nova Scotia hanno identificato un meccanismo chiave delle metastasi tumorali che potrebbe portare al blocco della crescita tumorale.
I ricercatori hanno scoperto che sulla superficie esterna dei macrofagi esiste una proteina chiamata S100A10, che consente ai macrofagi di rimuovere le barriere del tessuto accelerando la migrazione delle cellule tumorali verso altri punti del corpo.
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I have few questions more than a comment.
My question are:
1.- Is the S100A10 the same protein known as p11 essential in the regulation of serotonin signaling in the brain?
http://en.wikipedia.org/wiki/S100A10
The p11 protein has been intimately linked to mood disorders, to be specific, depression, due to its role in serotonin systems via its interactions with serotonin 5-HT receptors. Serotonin affects diverse systems including the cardiovascular, renal, immune, and gastrointestinal systems. Current research focuses on the neurotransmitter’s relationship with mood-regulation.
2.- Is there any relationship to the possibility of acting in tumor proliferation (metastasis)and the neurological disorders?
3. – Do you have any information if this S1000A10 may play a role in migraine? In many casis migrain is relief by treatment with triptans (which is a selective serotonin receptor agonist)?
Recent studies show that protein p11 increases the concentration of the serotonin 5-HT receptors at neuronal synapses, thereby rendering serotonin signaling much more efficient.
4. – Could triptanes play a role in the metastatization process?
Regards
Dr. Terenzio Facchinetti
tel +49 162 262 1912
terenzio.facchinetti@ul.com